Microbiome

The gut microbiome plays a key role in supporting overall health.

In recent years, growing research has revealed that the microbes living in and on our bodies may have profound influences on health. The human microbiome encompasses all the microbes associated with the human body, including gut, skin, respiratory tract, urogenital tract and other body sites. While the term microbiota refers to the microorganisms themselves (which may include bacteria, fungi and viruses), the term microbiome includes the microorganisms along with their collective genomes and metabolites (the molecules they produce).

Inside the gut, normal microbial residents as well as the microbes we eat are constantly interacting with our human cells, including cells of the gut wall and immune system. Beneficial interactions can reinforce the barrier function of the intestinal lining, decreasing passage of bacteria or outside substances from the intestine into the bloodstream, and serve to stimulate the immune system for optimal functioning. Not all actions of the microbiome are positive, however, and some microbial activities are thought to contribute to poor health. Research is underway to determine which gut microbes lead to which health outcomes, and how to modify them to support better health.

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More Resources on Microbiome

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  • Bugs on the Brain: the Microbiota-Gut-Brain Axis

  • You Have the Microbiota You Deserve!

  • Antibiotics: Use with Caution

  • Got gas? Blame it on your bacteria

  • 2024 highlights in biotic science, with ISAPP’s current and past Presidents

  • Archive Highlight: The role of microbes in gut-brain communication, with Prof. Emeran Mayer MD

  • Episode 36: Uncovering the mechanisms of sorbitol intolerance, with Dr. Jee-Yon Lee MD PhD

  • Episode 31: Microbial species and strains: What’s in a name?

  • Episode 30: A systems biology perspective on the gut microbiome

  • Episode 28: Lactobacilli in the microbiomes of the gut, skin, reproductive tract and more