c. difficile

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  • Emerging clinical insights into C. difficile infection from gut microbiota research
    In recent years the clinical status and spectrum of C. difficile infection have shifted. The prevalence of this infection has risen sharply. Along with changes that have occurred in the clinical patterns of this disorder, research on the gut microbiome has provided insights into the important factors that contribute to the infection.

  • The American College of Gastroenterology recommends against use of probiotics for primary or secondary prevention of C. difficile
    We are not convinced that the paper’s authors have justified their recommendation against the use of probiotics in relation to CDI prevention. They fail to clarify why the results of their GRADE evaluation of probiotic evidence for prevention of C. difficile resulted in totally different conclusions compared to the AGA document, which found evidence sufficient for conditional recommendation of four probiotic preparations.