The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health

Although the term “gut health” is used frequently, it previously had no scientific definition. ISAPP led an expert scientific panel that met to discuss the current state of scientific and clinical knowledge on the physiology, manifestation, application and measurement of the concept of gut health. The definition of gut health advanced by this panel is “a state of normal gastrointestinal function without active gastrointestinal disease and gut-related symptoms that affect quality of life”. Six domains of gut health are delineated in this paper, and appropriate measurements are discussed, with implications for a wide range of future research studies and clinical applications.

REFERENCE:

Marco ML, Cunningham M, Bischoff SC, Clarke G, Delzenne N, Lewis JD, Meisel M, Merenstein D, O’Toole PW, Staudacher HM, Szajewska H, Wells JM, Quigley EMM. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health. Nat Rev Gastroenterol Hepatol. 2026.