Publications by ISAPP Board

Selected Publications by ISAPP Board

For publications from the overall organization or those related to microbiome research in the broader scientific community, please visit:

ISAPP Publications 

Resources related to probiotics, prebiotics, gut health, fermented foods, microbiomes or similar. 

Michael Cabana, MD, MPH

  • Cabana MD, McKean M, Caughey AB, Fong L, Synch S, Wong A, Leong R, Boushey HA, Hilton JF. Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial. Pediatrics. 2017; 140; e20163000; DOI: 10.1542/peds.2016-3000. PMID: 28784701
  • Sanders ME, Merenstein DJ, Ouwehand AC, Reid G, Salminen S, Cabana MD, Paraskevakos G, Leyer G. Probiotic use in at-risk populations. J Am Pharm Assoc.2016;56:680-686. PMID: 27836128
  • Van den Nieuwboer M, Brummer RJ, Guarner F, Morelli L, Cabana MD, Claassen E. Safety of probiotics and synbiotics in children under 18 years of age.  Benef Microbes. 2015; 6: 615-30.  PMID:25809217
  • Sung V, Cabana MD, D’Amico F, Deshpande G, Dupont C, Indrio F, Mentula S, Partty A, Savino F, Szajewska H, Tancredi D. Lactobacillus reuteri DSM 17938 for managing infant colic: protocol for an individual participant data meta-analysis. BMJ Open. 2014; 4: e006475. PMID:25475244
  • Sung V, Cabana MD. Probiotics for colic: is the gut responsible for infant crying after all?  J Pediatr. 2017; 191:6-8.
  • Sung V, D’Amico F, Cabana, MD, et al. Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis. Pediatrics. 2017; pii: e20171811. doi: 10.1542/peds.2017-1811[Epub ahead of print]
  • Cabana MD, Shane AL, Chao C, Oliva-Hemker M. Probiotics in primary care pediatrics. Clin Peds. 2006;45:405-410
  • Cabana MD, McKean M, Wong AR, Chao C, Caughey AB. Examining the hygiene hypothesis: the Trial of Infant Probiotic Supplementation. Paediatr Perinat Epid. 2007; 21:s23-28.
  • Lenoir-Wijnkoop I, Sanders ME, Cabana MD, Van Loo J, Sherman PM, Rayes N, Timmerman HM, Corthier G, Vaneechoutte M, Caglar E, Volvers DAW. Probiotic and probiotic influence beyond the intestinal tract. Nutrition Reviews. 2007;65:469-89
Glenn Gibson, Ph.D.

Colin Hill, Ph.D.

Robert Hutkins, Ph.D.

  • Davis, L., I. Martinez, J. Walter, and R. Hutkins. 2010. A dose dependent impact of prebiotic galactooligosaccharides on the intestinal microbiota of healthy adults. Int. J. Food Microbiol. 144:285–292.
  • Davis, L., I. Martinez, J. Walter, C. Goin, and R. Hutkins. 2011. Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans. PLoS One 6(9):e25200.
  • Hartzell, A.L., M.X. Maldonado, R.W. Hutkins, and D.J. Rose. 2013. In vitro digestion and fermentation of 5-formyl-aminosailcylate-inulin: a potential prodrug of 5-aminosalicylic acid. Bioactive Carbohydr. Dietary Fibre  2:8-14.
  • Quintero, M., B. Aam, J. Rupnow, M. Sørlie, V. Eijsink, and R.W. Hutkins. 2013. Adherence inhibition of enteropathogenic Escherichia coli by chitooligosaccharides with specific degrees of acetylation and polymerization. J. Ag. Food Chem. 61:2748−2754.
  • Rattanaprasert, M., S. Roos, J.Walter and R.W. Hutkins. 2014. Quantitative evaluation of synbiotic strategies to improve persistence and metabolic activity of Lactobacillus reuteri DSM 17938 in the human gastrointestinal tract. J. Functional Foods 10:85-94.
  • Maldonado-Gomez, M.X., H. Lee, D. Barile, M. Lu, and R.W. Hutkins. 2015. Adherence inhibition of enteric pathogens to epithelial cells by bovine colostrum fractions. Int. Dairy J. 40:24-32.
  • Krumbeck, J.A., M.X. Maldonado-Gomez, I. Martínez, S.A. Frese, T.E. Burkey, K. Rasineni, A.E. Ramer-Tait, E.N. Harris, R.W. Hutkins, and J. Walter. 2015. In vivo selection to identify bacterial strains with enhanced ecological performance in synbiotic applications. Appl. Environ. Microbiol. 81:2445-2465.
  • Hutkins, R.W., J.A. Krumbeck, L.B. Bindels, P.D. Cani, G. Fahey, Jr., Y.J. Goh, B. Hamaker, E.C. Martens, D.A. Mills, R.A. Rastal, E. Vaughan, and M.E. Sanders. 2016. Prebiotics: why definitions matter. Curr. Opin. Biotechnol. 37:1–7.
  • Krumbeck, J.A. N.L. Marsteller, S.A. Frese, D.A. Peterson, A.E. Ramer-Tait, R.W. Hutkins, and J. Walter. 2016. Characterization of the ecological role of genes mediating acid resistance in Lactobacillus reuteri during colonization of the gastrointestinal tract. Environ. Microbiol. doi:10.1111/1462-2920.13108.
  • Krumbeck, J.A., M.X. Maldonado-Gomez, A.E. Ramer-Tait, and R.W. Hutkins. 2016. Prebiotics and synbiotics – dietary strategies for improving gut health. Curr. Opin. Gastroenterol. In Press.
Sarah, Lebeer, Ph.D.
  • Broeckx G, Vandenheuvel D, Claes IJ, Lebeer S, Kiekens F. (2016). Drying techniques of probiotic bacteria as an important step towards the development of novel pharmabiotics. Int J Pharm. 2016 May 30;505(1-2):303-18.
  • Petrova MI, Lievens E, Verhoeven TL, Macklaim JM, Gloor G, Schols D, Vanderleyden J, Reid G, Lebeer S. (2016). The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens. Sci Rep. 6:37437
  • Tytgat HL, van Teijlingen NH, Sullan RM, Douillard FP, Rasinkangas P, Messing M, Reunanen J, Satokari R, Vanderleyden J, Dufrêne YF, Geijtenbeek TB, de Vos WM, Lebeer S. (2016). Probiotic gut microbiota Isolate Interacts with dendritic cells via glycosylated heterotrimeric pili. PLoS One. 11(3):e0151824.
  • Petrova MI, Lievens E, Malik S, Imholz N, Lebeer S. (2015). Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. Front Physiol.6:81.
  • Vargas García CE, Petrova M, Claes IJ, De Boeck I, Verhoeven TL, Dilissen E, von Ossowski I, Palva A, Bullens DM, Vanderleyden J, Lebeer S. (2015). Piliation of Lactobacillus rhamnosus GG promotes adhesion, phagocytosis, and cytokine modulation in macrophages. Appl Environ Microbiol. 81(6):2050-62.
  • Claes IJ, Vargas García CE, Lebeer S. (2015). Novel opportunities for the exploitation of host-microbiome interactions in the intestine. Curr Opin Biotechnol. 32:28-34.
  • Segers ME, Lebeer S. (2014). Towards a better understanding of Lactobacillus rhamnosus GG–host interactions. Microb Cell Fact. 13 Suppl 1:S7.
  • Tripathi P, Beaussart A, Alsteens D, Dupres V, Claes I, von Ossowski I, de Vos WM, Palva A, Lebeer S, Vanderleyden J, Dufrêne YF. (2013). Adhesion and nanomechanics of pili from the probiotic Lactobacillus rhamnosus GG. ACS Nano. (4):3685-97.
  • Lebeer S, Claes IJ, Vanderleyden J. (2012). Anti-inflammatory potential of probiotics: lipoteichoic acid makes a difference. Trends Microbiol. 20(1):5-10.
  • Lebeer S, Vanderleyden J, De Keersmaecker SC. (2010). Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nat Rev Microbiol. 8(3):171-84.
Daniel Merenstein, MD

  • Merenstein D, Foster J, D’Amico F. A randomized clinical trial measuring the influence of kefir on antibiotic-associated diarrhea: the measuring the Influence of Kefir (MILK) Study. Arch Pediatr Adolesc Med. Aug:163(8);750-4, 2009.
  • Merenstein D, Smith KH, Scriven M, Roberts RF, Sanders ME, Petterson S. The study to investigate the potential benefits of probiotics in yogurt, a patient-oriented, double-blind, cluster-randomised, placebo-controlled, clinical trial.  Eur J Clin Nutr. Jul;64(7):685-91.
  • Merenstein D, Murphy M, Fokar A, Hernandez RK, Park H, Nsouli H, Sanders ME, Davis BA, Niborski V, Tondu F, Shara NM. Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study. A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial. Eur J Clin Nutr. 2010 Jul;64(7):669-77.
  • Murphy M and Merenstein D. Grassroots Campaign Trail Methods to Recruit for Clinical Trials: Recruitment Lessons Learned from Trail to Trial. Clinical Medicine Insights: Pediatrics 2011:5 1-7.
  • Merenstein D, Gonzalez J, Young AG, Roberts RF, Sanders ME, Petterson S. Study to investigate the potential of probiotics in children attending school. Eur J Clin Nutr. 2011 Apr;65(4):447-53.
  • Merenstein D, Hu H, Wang C, Hamilton P, Blackmon M, Chen H, Calderone R, Li D. Colonization by Candida Species of the Oral and Vaginal Mucosa in HIV-Infected and Noninfected Women. AIDS Res Hum Retroviruses. 2013 Jan;29(1):30-4.
  • Shane AL, Deshpande GC, Merenstein D. Improved Neonatal Outcomes With Probiotics. JAMA Pediatr. 2013 Oct 1;167(10):885-886.
  • Merenstein DJ, D’Amico F, Palese C, Hahn A, Sparenborg J, Tan T, Scott H, Polzin K, Kolberg L, Roberts R. Short-term, daily intake of yogurt containing Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24384) does not affect colonic transit time in women. Br J Nutr. 2013 Oct 8:1-8.
  • Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14.
  • Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: a phase I safety study. Merenstein DJ, Tan TP, Molokin A, Smith KH, Roberts RF, Shara NM, Mete M, Sanders ME, Solano-Aguilar G. Gut Microbes. 2015;6(1):66-77. doi: 10.1080/19490976.2015.1005484.
Eamonn Quigley, MD
Gregor Reid, Ph.D., MBA, Dr, HS

  • Smit, S., J. Leach, G. E. D. Sonnenburg, C. G. Gonzalez, J. S. Lichtman, G. Reid, R. Knight, A. Manjurano, J. Changalucha, J. E. Elias, M. Gloria Dominguez-Bellow, and J.L.  Sonnenburg. 2017. Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania. Science 357: 802-806.
  • Daisley, B. A., M. Trinder, T.W. McDowell, H. Welle, J. S. Dube, H. Leong, M. Sumarah, and G. Reid. 2017. Common neonicotinoid insecticide, imidacloprid, impairs insect tolerance to infection and environmental stressors. Sci. Reports 7: 1-12.
  • Reid, G. 2017. The development of probiotics for women’s health. Can. J. Microbiol. 63:1-9.
  • Reid, G., and J. P. Burton. 2016. Making sense of urinary microbiota data for clinical urology. Nature Rev. Urol. 13(10):567-8.
  • McMillan, A., S. Rulisa, M. Sumarah, J. M. Macklaim, J. Renaud, J. E. Bisanz, G. B. Gloor, and G. Reid. 2015. A multi-platform metabolomics approach identifies highly specific biomarkers of bacterial diversity in the vagina of pregnant and non-pregnant women. Sci. Reports 5:14174.
  • Bisanz, J. E. M. Enos, J. Mwanga, J. Changalucha, J. P. Burton, G. B. Gloor, and G. Reid. 2014. Investigating the use of probiotics and the role of the gut microbiome in toxic metal exposure in at-risk populations in Mwanza, Tanzania.  mBio Oct 7;5(5). pii: e01580-14.
  • Urbaniak, C., J. Cummins, M. Brackstone, J. M. Macklaim, C. K. Baban, L. Scott, D. M. O’Hanlon, M. Angelini, J. P. Burton, G. B. Gloor, K. Francis, M. Tangay, and G. Reid. 2013. Microbiota of the breast tissue. Appl. Environ. Microbiol. 80(10):3007-14.
  • Macklaim, J. M., A. D. Fernandes, G. Reid, and G. B. Gloor. 2013. Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis. Microbiome 1:12.
  • Reid, G., J. Younes, H. C. van der Mei, G. B. Gloor, R. Knight, and H. J. Busscher. 2011. Microbiota Restoration: natural and supplemented recovery of human microbial communities. Nat. Rev. Microbiol. 9(1):27-38.
  • Macklaim, J., G. B. Gloor, K. C. Anukam, S. Cribby, and G. Reid. 2011. At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners. Proc. Nat. Acad. Sci (USA) 108 Suppl 1:4688-95.
Seppo Salminen, Ph.D.

  • Lahtinen P, Mattila E, Anttila VJ, Tillonen J, Teittinen M, Nevalainen P,Salminen S, Satokari R, Arkkila P. Faecal microbiota transplantation in patients with Clostridium difficile and significant comorbidities as well as in patientswith new indications: A case series. World J Gastroenterol. 2017 Oct21;23(39):7174-7184.
  • Brodmann T, Endo A, Gueimonde M, Vinderola G, Kneifel W, de Vos WM, SalminenS, Gómez-Gallego C. Safety of Novel Microbes for Human Consumption: PracticalExamples of Assessment in the European Union. Front Microbiol. 2017 Sep12;8:1725. doi: 10.3389/fmicb.2017.01725. eCollection 2017.
  • Kumbhare SV, Kumar H, Chowdhury SP, Dhotre DP, Endo A, Mättö J, Ouwehand AC,Rautava S, Joshi R, Patil NP, Patil RH, Isolauri E, Bavdekar AR, Salminen S,Shouche YS. A cross-sectional comparative study of gut bacterial community ofIndian and Finnish children. Sci Rep. 2017 Sep 5;7(1):10555. doi:10.1038/s41598-017-11215-y.
  • Gómez-Gallego C, Junnila J, Männikkö S, Hämeenoja P, Valtonen E, Salminen S,Beasley S. A canine-specific probiotic product in treating acute or intermittent diarrhea in dogs: A double-blind placebo-controlled efficacy study. VetMicrobiol. 2016 Dec 25;197:122-128.
  • Lundelin K, Poussa T, Salminen S, Isolauri E. Long-term safety and efficacy ofperinatal probiotic intervention: Evidence from a follow-up study of fourrandomized, double-blind, placebo-controlled trials. Pediatr Allergy Immunol.2017 Mar;28(2):170-175.
  • Maeno S, Tanizawa Y, Kanesaki Y, Kubota E, Kumar H, Dicks L, Salminen S,Nakagawa J, Arita M, Endo A. Genomic characterization of a fructophilic beesymbiont Lactobacillus kunkeei reveals its niche-specific adaptation. Syst ApplMicrobiol. 2016 Dec;39(8):516-526.
  • Harata G, Kumar H, He F, Miyazawa K, Yoda K, Kawase M, Kubota A, Hiramatsu M, Rautava S, Salminen S. Probiotics modulate gut microbiota and health status inJapanese cedar pollinosis patients during the pollen season. Eur J Nutr. 2017Oct;56(7):2245-2253.
  • Gómez-Gallego C, Pohl S, Salminen S, De Vos WM, Kneifel W. Akkermansiamuciniphila: a novel functional microbe with probiotic properties. BenefMicrobes. 2016 Sep;7(4):571-84.
  • Collado MC, Rautava S, Aakko J, Isolauri E, Salminen S. Human gut colonisationmay be initiated in utero by distinct microbial communities in the placenta andamniotic fluid. Sci Rep. 2016 Mar 22;6:23129. doi: 10.1038/srep23129
  • Kumbhare SV, Kumar H, Chowdhury SP, Dhotre DP, Endo A, Mättö J, Ouwehand AC,Rautava S, Joshi R, Patil NP, Patil RH, Isolauri E, Bavdekar AR, Salminen S,Shouche YS. A cross-sectional comparative study of gut bacterial community of Indian and Finnish children. Sci Rep. 2017 Sep 5;7(1):10555.
Mary Ellen Sanders, Ph.D.

Karen Scott, Ph.D.

  • Scott K. P., Martin, J. C., Duncan, S. H. & Flint, H. J. 2014 Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro.  FEMS Microbiol Ecol 87, 30-40.
  • Scott, K.P., Duncan, S.H., Louis, P., Flint, H.J. Micro-organisms in the human gut – Diversity and function. (2011) Biochemist, 33 (4), pp. 4-9.
  • Scott, K.P., Duncan, S.H., Louis, P., Flint, H.J. Nutritional influences on the gut microbiota and the consequences for gastrointestinal health. (2011) Biochemical Society Transactions, 39 (4), pp. 1073-1078.
  • Scott, K.P., Martin, J.C., Chassard, C., Clerget, M., Potrykus, J., Campbell, G., Mayer, C.-D., Young, P., Rucklidge, G., Ramsay, A.G., Flint, H.J. Substrate-driven gene expression in Roseburia inulinivorans: Importance of inducible enzymes in the utilization of inulin and starch. (2011) Proceedings of the National Academy of Sciences of the United States of America, 108 (SUPPL. 1), pp. 4672-4679.
  • Seville, L.A., Patterson, A.J., Scott, K.P., Mullany, P., Quail, M.A., Parkhill, J., Ready, D., Wilson, M., Spratt, D., Roberts, A.P. Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA. (2009) Microbial Drug Resistance, 15 (3), pp. 159-166.
  • Kazimierczak, K.A., Scott, K.P., Kelly, D., Aminov, R.I. Tetracycline resistome of the organic pig gut. (2009) Applied and Environmental Microbiology, 75 (6), pp. 1717-1722.