Publications by ISAPP Board

Selected Publications by ISAPP Board

For publications from the overall organization or those related to microbiome research in the broader scientific community, please visit:

ISAPP Publications 

Resources related to probiotics, prebiotics, gut health, fermented foods, microbiomes or similar. 

Michael Cabana, MD, MPH

  • Cabana MD, Shane AL, Chao C, Oliva-Hemker M. Probiotics in primary care pediatrics. Clin Peds. 2006;45:405-410.
  • Cabana MD, McKean M, Wong AR, Chao C, Caughey AB. Examining the hygiene hypothesis: the Trial of Infant Probiotic Supplementation. Paediatr Perinat Epid. 2007; 21:s23-28.
  • Lenoir-Wijnkoop I, Sanders ME, Cabana MD, Van Loo J, Sherman PM, Rayes N, Timmerman HM, Corthier G, Vaneechoutte M, Caglar E, Volvers DAW. Probiotic and probiotic influence beyond the intestinal tract. Nutrition Reviews. 2007;65:469-89


  • Cabana MD, Shane AL, Chao C, Oliva-Hemker M. Probiotics in primary care pediatrics. Clin Peds. 2006;45:405-410.
  • Cabana MD, McKean M, Wong AR, Chao C, Caughey AB. Examining the hygiene hypothesis: the Trial of Infant Probiotic Supplementation. Paediatr Perinat Epid. 2007; 21:s23-28.
  • Lenoir-Wijnkoop I, Sanders ME, Cabana MD, Van Loo J, Sherman PM, Rayes N, Timmerman HM, Corthier G, Vaneechoutte M, Caglar E, Volvers DAW. Probiotic and probiotic influence beyond the intestinal tract. Nutrition Reviews. 2007;65:469-89
Glenn Gibson, Ph.D.

Colin Hill, Ph.D.

Robert Hutkins, Ph.D.

  • Davis, L., I. Martinez, J. Walter, and R. Hutkins. 2010. A dose dependent impact of prebiotic galactooligosaccharides on the intestinal microbiota of healthy adults. Int. J. Food Microbiol. 144:285–292.
  • Davis, L., I. Martinez, J. Walter, C. Goin, and R. Hutkins. 2011. Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans. PLoS One 6(9):e25200.
  • Hartzell, A.L., M.X. Maldonado, R.W. Hutkins, and D.J. Rose. 2013. In vitro digestion and fermentation of 5-formyl-aminosailcylate-inulin: a potential prodrug of 5-aminosalicylic acid. Bioactive Carbohydr. Dietary Fibre  2:8-14.
  • Quintero, M., B. Aam, J. Rupnow, M. Sørlie, V. Eijsink, and R.W. Hutkins. 2013. Adherence inhibition of enteropathogenic Escherichia coli by chitooligosaccharides with specific degrees of acetylation and polymerization. J. Ag. Food Chem. 61:2748−2754.
  • Rattanaprasert, M., S. Roos, J.Walter and R.W. Hutkins. 2014. Quantitative evaluation of synbiotic strategies to improve persistence and metabolic activity of Lactobacillus reuteri DSM 17938 in the human gastrointestinal tract. J. Functional Foods 10:85-94.
  • Maldonado-Gomez, M.X., H. Lee, D. Barile, M. Lu, and R.W. Hutkins. 2015. Adherence inhibition of enteric pathogens to epithelial cells by bovine colostrum fractions. Int. Dairy J. 40:24-32.
  • Krumbeck, J.A., M.X. Maldonado-Gomez, I. Martínez, S.A. Frese, T.E. Burkey, K. Rasineni, A.E. Ramer-Tait, E.N. Harris, R.W. Hutkins, and J. Walter. 2015. In vivo selection to identify bacterial strains with enhanced ecological performance in synbiotic applications. Appl. Environ. Microbiol. 81:2445-2465.
  • Hutkins, R.W., J.A. Krumbeck, L.B. Bindels, P.D. Cani, G. Fahey, Jr., Y.J. Goh, B. Hamaker, E.C. Martens, D.A. Mills, R.A. Rastal, E. Vaughan, and M.E. Sanders. 2016. Prebiotics: why definitions matter. Curr. Opin. Biotechnol. 37:1–7.
  • Krumbeck, J.A. N.L. Marsteller, S.A. Frese, D.A. Peterson, A.E. Ramer-Tait, R.W. Hutkins, and J. Walter. 2016. Characterization of the ecological role of genes mediating acid resistance in Lactobacillus reuteri during colonization of the gastrointestinal tract. Environ. Microbiol. doi:10.1111/1462-2920.13108.
  • Krumbeck, J.A., M.X. Maldonado-Gomez, A.E. Ramer-Tait, and R.W. Hutkins. 2016. Prebiotics and synbiotics – dietary strategies for improving gut health. Curr. Opin. Gastroenterol. In Press.
Sarah, Lebeer, Ph.D.
  • Broeckx G, Vandenheuvel D, Claes IJ, Lebeer S, Kiekens F. (2016). Drying techniques of probiotic bacteria as an important step towards the development of novel pharmabiotics. Int J Pharm. 2016 May 30;505(1-2):303-18.
  • Petrova MI, Lievens E, Verhoeven TL, Macklaim JM, Gloor G, Schols D, Vanderleyden J, Reid G, Lebeer S. (2016). The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens. Sci Rep. 6:37437
  • Tytgat HL, van Teijlingen NH, Sullan RM, Douillard FP, Rasinkangas P, Messing M, Reunanen J, Satokari R, Vanderleyden J, Dufrêne YF, Geijtenbeek TB, de Vos WM, Lebeer S. (2016). Probiotic gut microbiota Isolate Interacts with dendritic cells via glycosylated heterotrimeric pili. PLoS One. 11(3):e0151824.
  • Petrova MI, Lievens E, Malik S, Imholz N, Lebeer S. (2015). Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. Front Physiol.6:81.
  • Vargas García CE, Petrova M, Claes IJ, De Boeck I, Verhoeven TL, Dilissen E, von Ossowski I, Palva A, Bullens DM, Vanderleyden J, Lebeer S. (2015). Piliation of Lactobacillus rhamnosus GG promotes adhesion, phagocytosis, and cytokine modulation in macrophages. Appl Environ Microbiol. 81(6):2050-62.
  • Claes IJ, Vargas García CE, Lebeer S. (2015). Novel opportunities for the exploitation of host-microbiome interactions in the intestine. Curr Opin Biotechnol. 32:28-34.
  • Segers ME, Lebeer S. (2014). Towards a better understanding of Lactobacillus rhamnosus GG–host interactions. Microb Cell Fact. 13 Suppl 1:S7.
  • Tripathi P, Beaussart A, Alsteens D, Dupres V, Claes I, von Ossowski I, de Vos WM, Palva A, Lebeer S, Vanderleyden J, Dufrêne YF. (2013). Adhesion and nanomechanics of pili from the probiotic Lactobacillus rhamnosus GG. ACS Nano. (4):3685-97.
  • Lebeer S, Claes IJ, Vanderleyden J. (2012). Anti-inflammatory potential of probiotics: lipoteichoic acid makes a difference. Trends Microbiol. 20(1):5-10.
  • Lebeer S, Vanderleyden J, De Keersmaecker SC. (2010). Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nat Rev Microbiol. 8(3):171-84.
Daniel Merenstein, MD

  • Merenstein D, Foster J, D’Amico F. A randomized clinical trial measuring the influence of kefir on antibiotic-associated diarrhea: the measuring the Influence of Kefir (MILK) Study. Arch Pediatr Adolesc Med. Aug:163(8);750-4, 2009.
  • Merenstein D, Smith KH, Scriven M, Roberts RF, Sanders ME, Petterson S. The study to investigate the potential benefits of probiotics in yogurt, a patient-oriented, double-blind, cluster-randomised, placebo-controlled, clinical trial.  Eur J Clin Nutr. Jul;64(7):685-91.
  • Merenstein D, Murphy M, Fokar A, Hernandez RK, Park H, Nsouli H, Sanders ME, Davis BA, Niborski V, Tondu F, Shara NM. Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study. A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial. Eur J Clin Nutr. 2010 Jul;64(7):669-77.
  • Murphy M and Merenstein D. Grassroots Campaign Trail Methods to Recruit for Clinical Trials: Recruitment Lessons Learned from Trail to Trial. Clinical Medicine Insights: Pediatrics 2011:5 1-7.
  • Merenstein D, Gonzalez J, Young AG, Roberts RF, Sanders ME, Petterson S. Study to investigate the potential of probiotics in children attending school. Eur J Clin Nutr. 2011 Apr;65(4):447-53.
  • Merenstein D, Hu H, Wang C, Hamilton P, Blackmon M, Chen H, Calderone R, Li D. Colonization by Candida Species of the Oral and Vaginal Mucosa in HIV-Infected and Noninfected Women. AIDS Res Hum Retroviruses. 2013 Jan;29(1):30-4.
  • Shane AL, Deshpande GC, Merenstein D. Improved Neonatal Outcomes With Probiotics. JAMA Pediatr. 2013 Oct 1;167(10):885-886.
  • Merenstein DJ, D’Amico F, Palese C, Hahn A, Sparenborg J, Tan T, Scott H, Polzin K, Kolberg L, Roberts R. Short-term, daily intake of yogurt containing Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24384) does not affect colonic transit time in women. Br J Nutr. 2013 Oct 8:1-8.
  • Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14.
  • Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: a phase I safety study. Merenstein DJ, Tan TP, Molokin A, Smith KH, Roberts RF, Shara NM, Mete M, Sanders ME, Solano-Aguilar G. Gut Microbes. 2015;6(1):66-77. doi: 10.1080/19490976.2015.1005484.
Eamonn Quigley, MD
  • Marques TM, Wall R, O’Sullivan O, Fitzgerald GF, Shanahan F, Quigley EM, Cotter PD, Cryan JF, Dinan TG, Ross RP, Stanton C.Dietary trans-10, cis-12-conjugated linoleic acid alters fatty acid metabolism and microbiota composition in mice. Br J Nutr. 2015 [Epub ahead of print]
  • Moayyedi P, Quigley EM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, Soffer EE, Spiegel BM, Ford AC. The Effect of Dietary Intervention on Irritable Bowel Syndrome:  A Systematic Review.  Clin Transl Gastroenterol.  2015; 6:e107.
  • Victor DW 3rd, Quigley EM. The Microbiome and the Liver: The Basics. Semin Liver Dis. 2016;36:299-305.
  • Monsour HP Jr, Quigley EM. The Microbiome: What Will the Future Hold? Semin Liver Dis. 2016;36:354-359.
  • Quigley EM. Editorial: balancing fibre and FODMAPs in IBS – a ‘rye’ look at an old problem. Aliment Pharmacol Ther. 2016;44:1134-1135.
  • Stanisic V and Quigley EMM.  Role of the intestinal microbiota and probiotics in health and disease.  In:  Buchman AL, ed. Nutritional Care of the Patient with Gastrointestinal Disease.  CRC Press, Boca Raton 2016 pp 111-132.
  • Abraham BP, Quigley EMM. Prebiotics and probiotics in inflammatory bowel disease (IBD). In: Ananthakrishnan A, eds. Nutritional Management of Inflammatory Bowel Disease. New York, Springer 2016. pp 131-147.
  • Quigley EMM. The gut microbiota and irritable bowel syndrome (IBS). In: Johnson DA, ed. The Gut Microbiome. New understanding and potential translational applications for disease management. New York, Nova Biomedical 2016 pp 129-142.
  • Quigley EMM. Luminally Active Therapies: Pancreatic Enzymes, Bile Acids, Bile Acid Binders, Antimicrobials, Probiotics, and Prebiotics in Short Bowel Syndrome. In: DiBaise JK, Parrish CR, Thompson JS. Eds.  Short Bowel Syndrome. Practical Approach to Management. Boca Raton, CRC Press 2016 pp 227-240.
  • Quigley EM, Barbara G, Feinle-Biset C, Ghoshal UC, Santos J, Vanner S, Vergnolle N, Zoetendal EG. The intestinal microenvironment and functional gastrointestinal disorders. In: Drossman DA, Chang L, Chey WD, Kellow J, Tack J, Whitehead WE, and the Rome IV Committees. Rome IV Functional Gastrointestinal Disorders Disorders of Gut-Brain Interaction. Raleigh, The Rome Foundation 2016 pp 179-247.
  • Multiple articles on different bifidobacteria by Quigley EM, In: Floch MH, Ringel Y, Walker WA, eds. The microbiota in gastrointestinal pathophysiology. Implications for human health, prebiotics, probiotics and dysbiosis. London, Elsevier, Academic Press 2017.
Gregor Reid, Ph.D., MBA, Dr, HS

  • Urbaniak C, Reid G. The potential influence of the microbiota and probiotics on women during long spaceflights. Womens Health (Lond Engl). 2016 Mar;12(2):193-8.
  • Whiteside, S., H. Razvi, S.Dave, G. Reid, and J. P. Burton. 2015. The influence of the microbiome in urology goes beyond infection. Nature Urol. 12(2):81-90.
  • McMillan, A., S. Rulisa, M. Sumarah, J. M. Macklaim, J. Renaud, J. E. Bisanz, G. B. Gloor, and G. Reid. 2015. A multi-platform metabolomics approach identifies highly specific biomarkers of bacterial diversity in the vagina of pregnant and non-pregnant women. Scientific Reports Sep 21;5:14174.
  • Bisanz, J. E. M. Enos, J. Mwanga, J. Changalucha, J. P. Burton, G. B. Gloor, and G. Reid. 2014. Investigating the use of probiotics and the role of the gut microbiome in toxic metal exposure in at-risk populations in Mwanza, Tanzania.  mBio Oct 7;5(5). pii: e01580-14.
  • Urbaniak, C., J. Cummins, M. Brackstone, J. M. Macklaim, C. K. Baban, L. Scott, D. M. O’Hanlon, M. Angelini, J. P. Burton, G. B. Gloor, K. Francis, M. Tangay, and G. Reid. 2013. Microbiota of the breast tissue. Appl. Environ. Microbiol. 80(10):3007-14.
  • Macklaim, J. M., A. D. Fernandes, G. Reid, and G. B. Gloor. 2013. Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis. Microbiome 1:12.
  • Reid, G. 2012. Categorize probiotics to speed research. Nature 485: 446.
  • Bisanz, J., and G. Reid. 2011. Unraveling how probiotic yogurt works. Sci. Trans. Med. Oct 26;3(106):106ps41.
  • Reid, G., J. Younes, H. C. van der Mei, G. B. Gloor, R. Knight, and H. J. Busscher. 2011. Microbiota Restoration: natural and supplemented recovery of human microbial communities. Nat. Rev. Microbiol. 9(1):27-38.
  • Macklaim, J., G. B. Gloor, K. C. Anukam, S. Cribby, and G. Reid. 2011. At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners. Proc. Nat. Acad. Sci (USA) 108 Suppl 1:4688-95.
Seppo Salminen, Ph.D.

  • Luoto R, Ruuskanen O, Waris M, Kalliomäki M, Salminen S, Isolauri E. Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebo-controlled trial. J Allergy Clin Immunol. 2013 Oct 13. pii: S0091-6749(13)01307-9. doi: 10.1016/j.jaci.2013.08.020. [Epub ahead of print]
  • Rautava S, Luoto R, Salminen S, Isolauri E. Microbial contact during pregnancy, intestinal colonization and human disease. Nat Rev Gastroenterol Hepatol. 2012 Aug 14. doi: 10.1038/nrgastro.2012.144
  • Koren O, Goodrich JK, Cullender TC, Spor A, Laitinen K, Bäckhed HK, Gonzalez A, Werner JJ, Angenent LT, Knight R, Bäckhed F, Isolauri E, Salminen S, Ley RE. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell. 2012 Aug 3;150(3):470-80.
  • Cabrera-Rubio R, Collado MC, Laitinen K, Salminen S, Isolauri E, Mira A. The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery. Am J Clin Nutr. 2012 Sep;96(3):544-51.
  • Pärtty A, Kalliomäki M, Endo A, Salminen S, Isolauri E. Compositional development of Bifidobacterium and Lactobacillus microbiota is linked with crying and fussing in early infancy. PLoS One. 2012;7(3):e32495.
  • Grześkowiak Ł, Collado MC, Mangani C, Maleta K, Laitinen K, Ashorn P, Isolauri E, Salminen S. Distinct gut microbiota in southeastern African and northern European infants. J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):812-6.
  • van Loveren H, Sanz Y, Salminen S. Health claims in Europe: probiotics and prebiotics as case examples. Annu Rev Food Sci Technol. 2012;3:247-61.
  • Grönlund MM, Grześkowiak Ł, Isolauri E, Salminen S. Influence of mother’s intestinal microbiota on gut colonization in the infant. Gut Microbes. 2011 Jul-Aug;2(4):227-33.
Mary Ellen Sanders, Ph.D.

Karen Scott, Ph.D.

  • Scott K. P., Martin, J. C., Duncan, S. H. & Flint, H. J. 2014 Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro.  FEMS Microbiol Ecol 87, 30-40.
  • Scott, K.P., Duncan, S.H., Louis, P., Flint, H.J. Micro-organisms in the human gut – Diversity and function. (2011) Biochemist, 33 (4), pp. 4-9.
  • Scott, K.P., Duncan, S.H., Louis, P., Flint, H.J. Nutritional influences on the gut microbiota and the consequences for gastrointestinal health. (2011) Biochemical Society Transactions, 39 (4), pp. 1073-1078.
  • Scott, K.P., Martin, J.C., Chassard, C., Clerget, M., Potrykus, J., Campbell, G., Mayer, C.-D., Young, P., Rucklidge, G., Ramsay, A.G., Flint, H.J. Substrate-driven gene expression in Roseburia inulinivorans: Importance of inducible enzymes in the utilization of inulin and starch. (2011) Proceedings of the National Academy of Sciences of the United States of America, 108 (SUPPL. 1), pp. 4672-4679.
  • Seville, L.A., Patterson, A.J., Scott, K.P., Mullany, P., Quail, M.A., Parkhill, J., Ready, D., Wilson, M., Spratt, D., Roberts, A.P. Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA. (2009) Microbial Drug Resistance, 15 (3), pp. 159-166.
  • Kazimierczak, K.A., Scott, K.P., Kelly, D., Aminov, R.I. Tetracycline resistome of the organic pig gut. (2009) Applied and Environmental Microbiology, 75 (6), pp. 1717-1722.